6–11 Dec 2026
Stellenbosch University
Africa/Johannesburg timezone

Scalable On-Hardware Training of Quantum Neural Networks: Application to Clinical Data Imputation

Not scheduled
20m
Jan Mouton Learning Centre (Stellenbosch University)

Jan Mouton Learning Centre

Stellenbosch University

Poster

Speaker

Natansh Mathur

Description

Training quantum neural networks (QNNs) on quantum hardware is currently bottlenecked by the cost of gradient estimation: standard parameter-shift methods require a number of circuit evaluations that grows quadratically with the number of trainable parameters, making hardware-based optimisation impractical beyond small system sizes. In this work, we introduce a training framework that reduces this cost to logarithmic in the number of qubits.
Our framework combines three co-designed ingredients: (i) a structured, subspace-preserving Butterfly circuit architecture with $O(n \log n)$ parameters and logarithmic depth; (ii) a layer-wise training strategy that confines on-hardware optimisation to one small, well-structured layer at a time; and (iii) a parallelised parameter-shift rule that exploits the commuting structure within each Butterfly layer to extract all gradients in a constant number of circuit executions. Together these reduce the number of distinct circuit evaluations per optimisation step from $O(n^2)$ to $O(\log n)$.
We validate the framework on clinical data imputation using the MIMIC-III electronic health record dataset. Hybrid classical–quantum models are trained directly on IonQ Forte Enterprise trapped-ion hardware at 16 qubits without performance degradation relative to ideal or noisy simulation and via tensor-network simulation at 32 qubits, with 32-qubit inference executed on hardware.
The resulting models match or exceed strong classical neural baselines in downstream patient survival prediction, demonstrating that the proposed framework enables practical, scalable QNN training under realistic hardware constraints.

Topic Quantum variational circuits and their applications
Additional Topic Hybrid quantum-classical approaches for learning and optimization

Authors

Presentation materials